Thioctic Acid in the Treatment of Poisoning. with Alpha-Amanitin
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چکیده
Between August 8, 1974, and November 1, 1978, calls reporting 100 cases of mushroom poisoning were received by the National Institutes of Health. Thioctic acid was sent (under IND # 9957) for the treatment of seventy-five of these patients thought to have ingested mushrooms containing alpha-amanitin. Sixty-seven patients recovered, and eight died. The lapse of time between ingestion of mushrooms and the start of the protocol appears to be inversely related to the success of treatment. Serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase appear to be the best indices of the severity of poisoning. No toxicity attributable to thioctic acid was observed when thioctic acid was given from a container shielded from light, containing glucose, 5% and saline, 0.85%.
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